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Similarly, lower serum IGF-I levels are associated with increased AD risk and hippocampal atrophy [67]

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This activates key anabolic pathways—particularly the PI3K/Akt/mTOR cascade—which drives: → Muscle hypertrophy → Satellite cell recruitment → Protein synthesis → Tissue regeneration There are also synthetic analogs of IGF-1 used in performance enhancement: IGF-1 LR3 : A long-acting version that circulates systemically for up to 20–30 hours IGF-1 DES : A short-acting, 10x more potent version used for localized growth and recovery “IGF-1 is a critical growth factor that mediates skeletal muscle adaptation and regeneration, especially in response to overload and anabolic signaling.” — Glass, Nature Reviews Molecular Cell Biology IGF-1 can be administered via peptide injections for direct and targeted effects, making it especially popular among athletes seeking rapid hypertrophy , fat loss , and injury recovery